Quantitative polymorph contaminant analysis in tablets using Raman and near infra-red spectroscopies
نویسندگان
چکیده
منابع مشابه
Quantitative polymorph contaminant analysis in tablets using Raman and near infra-red spectroscopies.
The detection and quantification of alternate polymorphs of active pharmaceutical ingredients (APIs), particularly at low concentrations is a key issue for the manufacture and analysis of solid-state formulations. Each polymorph can possess unique physical and chemical properties which in turn can directly affect factors such as solubility and bioavailability. Near infra-red (NIR) and Raman spe...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical and Biomedical Analysis
سال: 2013
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2012.10.002